β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect
نویسندگان
چکیده
منابع مشابه
β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect
Over the past decade, screening and identifying novel compounds for their biomedical applications has become an upcoming area of research. Identifying the molecular mechanisms of these compounds has become an integral part of anticancer research. β-elemene, a sesquiterpene, is renowned for its anticancer activity against a variety of cell lines. Recent studies on β-elemene have elucidated that ...
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15 صفحه اولβ-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein.
β-elemene, extracted from the ginger plant, possesses antitumor activity against a broad range of cancers clinically. However, the mechanism underlying β-elemene-induced cytotoxicity remains incompletely understood. Here, we show that β-elemene promoted apoptotic cell death in human glioma cells, downregulated survivin gene expression, and induced...
متن کاملCombinatorial Antitumor Effect of Rapamycin and β-Elemene in Follicular Thyroid Cancer Cells
Background. mTOR signaling would be a promising target for thyroid cancer therapy. However, in clinical trials, objective response rate with mTOR inhibitor monotherapy in most cancer types was modest. A new focus on development of combinatorial strategies with rapalogs is increasing. Objective. Investigating the combinatorial antitumor effect of rapamycin and β-elemene in follicular thyroid can...
متن کاملThe effect of elemene on lung adenocarcinoma A549 cell radiosensitivity and elucidation of its mechanism
OBJECTIVE To investigate the effect of elemene on the radiosensitivity of A549 cells and its possible molecular mechanism. METHODS Apoptosis of A549 cells was detected by flow cytometry and fluorescence microscopy. The effect of double-strand break (DSB) damage repair in A549 cells was evaluated using the neutral comet assay. Protein expression levels were detected using western blotting, and...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2017
ISSN: 1663-9812
DOI: 10.3389/fphar.2017.00105